Modelling the spread of pandemic influenza and strategies for its containment and mitigation

FluModCont is a collaborative project funded by the Seventh Framework Programme (FP7), the EU’s main instrument for funding research in Europe.
Ten European research and health institutions have formed a consortium under a specific call by EC for the "Development of pandemic influenza containment and mitigation strategies". The call was issued in recognition of the fact, especially since the emergence and global spread of the highly pathogenic avian H5N1 virus, that the threat posed by novel strains of influenza A gaining transmissibility in people and causing a human pandemic was potentially catastrophic.
The emergence of the novel A/H1N1 swine flu strain has made the need to be prepared for an influenza pandemic even more obvious. Many researchers are working, in different areas of the world and generally in strict contact with public health authorities, on estimating the epidemiological features of the new strain, on modelling possible scenarios of the spread of A/H1N1 flu, and on the likely effect of countermeasures, from non-pharmaceutical interventions (such as closure of schools and isolation of potential case), to the use of antivirals or vaccination, in different epidemiological scenarios.
 

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Aim

Main objective of the project is arriving at an accurate and data-based modelling of the expected course of an influenza pandemic, and of the impact of public health measures on its scale and severity. Aims of the project include the study of the social acceptability of public health measures during a pandemic, and of the behavioural changes that are to be expected in such circumstances. Final aim will be the development of a knowledge-based computational environment necessary for real-time analysis and modelling in case of a pandemic.

(Expected) results

Improvement of the characterisation of population contact and travel patterns in epidemic models, on the basis of extended data collection, and model-driven extrapolations when data are lacking.
Evaluation of the social acceptance of restriction measures in case of a pandemic, and of the impact of behavioural changes on the expected epidemic course. Development of a suite of models for the spatio-temporal spread of a new influenza pandemic, that integrate the dual approaches of compartmental modelling and individual-based simulations.
Extensive evaluation of the impact of intervention options for containing and mitigating a pandemic influenza outbreak.
Development of an integrated environment for the efficient and extensible simulations of individual-based models.

Potential applications

Providing advice to the health authorities in case of a pandemic.
Development of a research team with rapid analysis capability in case of an epidemic outbreak.
 
 
 
 
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